Overview of Picked Chemical Compounds and Intermediates
Overview of Picked Chemical Compounds and Intermediates
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one. Pharmaceutical Intermediates
Bortezomib Acid Impurity: This can be an impurity relevant to bortezomib, a proteasome inhibitor Utilized in the procedure of various myeloma. Its synthesis or study is critical for making sure the purity and protection on the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-7): A precursor in the synthesis of abiraterone acetate, a drug Employed in the remedy of prostate cancer by inhibiting androgen generation.
Imatinib Intermediate (CAS NO. 152460-10-one): A essential compound within the synthesis of imatinib, a drug that targets unique sorts of cancer, which include Persistent myelogenous leukemia (CML).
Docetaxel Intermediate: A compound Employed in the synthesis of docetaxel, a chemotherapy medication that treats different cancers such as breast, lung, and prostate cancer.
two. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, eight): These are typically intermediates inside the synthesis of gemcitabine, an anti-most cancers drug. Their study is crucial for optimizing the creation system and ensuring significant purity.
Lapatinib Intermediate (CAS NO. 231278-eighty four-5): Lapatinib is utilised to take care of breast cancer, and these intermediates are associated with its output.
Fulvestrant Intermediates: Fulvestrant is surely an estrogen receptor antagonist Utilized in the treatment of breast cancer. A variety of intermediates help in the synthesis of the drug.
Paclitaxel Facet Chain Acid (CAS NO. 949023-sixteen-9): This intermediate is used in the synthesis of paclitaxel, a chemotherapy drug powerful in managing cancers which include ovarian, breast, and lung cancer.
3. Other Notable Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-3): A chemotherapy drug Utilized in the cure of colorectal most cancers and little cell 2-difluoro-D-erythro-pentofuranos-1-ulose-3 lung cancer.
3-Amino-1-hydroxyadamantane (CAS 702-82-nine): This compound is linked to the synthesis of adamantane derivatives, that have numerous programs, like antiviral Houses.
Vildagliptin Intermediates: Employed in the manufacture of vildagliptin, an oral drug for form two diabetic issues that inhibits the enzyme DPP-four to manage blood sugar stages.
4. Miscellaneous Compounds
D-Gluconic Acid δ-Lactone (CAS NO. 61259-48-one): This compound is linked to the synthesis of assorted gluconic acid derivatives, which are Employed in food stuff, pharmaceutical, and industrial purposes.
Canagliflozin Intermediate two: A precursor while in the synthesis of canagliflozin, a medication utilised to handle sort δ-lactone 2 diabetic issues by inhibiting sodium-glucose co-transporter two (SGLT2).